Dr. Lukas of Northwestern University Feinberg School of Medicine received honorariums from AbbVie as a guest speaker, from NewLink Genetics and Reneuron for consulting work, and from Monetris as an advisory board member.)
Cerebrovascular disease (sinus thrombosis, cerebral infarction, or hemorrhage) is a common complication of cancer and of cancer therapy. In this article, the authors review the clinical milieu in which these disorders develop and summarize the methods of diagnosis, including characteristic abnormalities of clinical findings, coagulation function tests, and neuroimaging. The management of these vascular disorders can be challenging in this patient population because of comorbidities associated with cancer. Some vascular disorders are unique to the cancer patient, including radiation-induced carotid artery atherosclerosis and chemotherapy-induced vasculopathy. Until recently, reports of these latter conditions were anecdotal and infrequent.
• Cancer is a hypercoagulable state leading to an increased risk of venous and arterial thromboembolic events.
• Cancer therapies such as radiation and chemotherapy have a range of adverse effects upon the CNS vasculature.
• Patients with cancer are also at risk for intracranial hemorrhage from a variety of factors including thrombocytopenia, coagulopathy, hemorrhagic brain metastases, and hematological malignancies.
Historical note and terminology
In the mid-1800s, Armand Trousseau first drew attention to the clinical association between thrombophlebitis and cancer. Subsequently, clinicians observed that thrombophlebitis is only 1 manifestation of a coagulopathy associated with cancer, which represents a disruption of the delicate balance that normally exists between hemorrhage and coagulation. This coagulopathy is poorly understood, and its mechanism is controversial. Disseminated intravascular coagulation is generally defined as excess thrombin generation within the vasculature that overwhelms normal regulatory hemostatic mechanisms. This results in increased consumption of platelets, coagulation factors, and sometimes inhibitors of coagulation. Defibrination syndrome and consumption coagulopathy are alternate terms for disseminated intravascular coagulation.
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