Historical note and terminology
Platelets are recognized to play a key role in the development of ischemic complications in the arterial circulation, and antiplatelet therapy has proven effective in the treatment and prevention of ischemic events. Aspirin was the first antiplatelet agent to become the gold standard in clinical practice. Clopidogrel was developed as a safer and more effective alternative to aspirin for the prevention and treatment of cerebral and cardiovascular ischemic events.
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