Galantamine

K K Jain MD (Dr. Jain is a consultant in neurology and has no relevant financial relationships to disclose.)
Originally released March 21, 2001; last updated March 6, 2016; expires March 6, 2019

Historical note and terminology

Cholinesterase inhibitors remain the dominant approach concerning the symptomatic treatment of Alzheimer disease. In 1993, tacrine was the first cholinesterase inhibitor approved by the Food and Drug Administration for use in Alzheimer disease. Following tacrine was the approval of donepezil in 1996 and rivastigmine in 2000. Galantamine (also called galanthamine in some studies) hydrobromide was approved in 2001 by the FDA. A solution preparation is also available for patients who either cannot swallow tablets or prefer liquid medications.

Galantamine was discovered accidentally in the 1950s by a Bulgarian pharmacologist in the bulbs and flowers of wild Caucasian snow drops, Galanthus woronowii (Sramek et al 2000). Initially, it was used as an agent to reverse the effect of curare in anesthetic practice.

The content you are trying to view is available only to logged in, current MedLink Neurology subscribers.

If you are a subscriber, please log in.

If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services. Site license users, click the Site License Acces link on the Homepage at an authorized computer.

If you have never registered before, click Learn More about MedLink Neurology  or view available Service Plans.