Historical note and terminology
Infliximab is a monoclonal antibody for the treatment of autoimmune diseases. Originally a mouse antibody, it was later developed into a human (humanized) antibody. Because it is a combination of mouse and human antibody, it is called a chimeric monoclonal antibody. The chimeric antibody was designed to reduce immunogenicity and improve pharmacokinetics in humans (Knight et al 1993). Infliximab has been approved by the United States Food and Drug Administration for the treatment of psoriasis, Crohn disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, sarcoidosis, and ulcerative colitis.
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