Multiple sclerosis: neuroimmunology
Anthony T Reder MD
(Dr. Reder of the University of Chicago served on advisory boards and as a consultant for Bayer, Biogen Idec, Caremark Rx, Genentech, Genzyme, Novartis, Questcor/Malinkrodt, Serono, and Teva-Marion.)
Originally released October 23, 2014; expires October 23, 2017
This article includes discussion of neuroimmunology and multiple sclerosis. The foregoing terms may include synonyms, similar disorders, variations in usage, and abbreviations.
• Multiple sclerosis is caused by immune attack against brain cells.
• There is no known multiple sclerosis antigen.
• The primary damage is oligodendroglia destruction and demyelination, but axons and neurons are also damaged.
• Cortical lesions are difficult to see on MRI; they affect cognition and progression.
• Interferon-alpha/beta levels in serum and responses to interferon are low in multiple sclerosis but high in neuromyelitis optica, before any therapy.
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