Sleep, trauma, and anxiety

Rebekah Jakel MD PhD (Dr. Jakel of Duke University has no relevant financial relationships to disclose.)
Antonio Culebras MD, editor. (Dr. Culebras of SUNY Upstate Medical University at Syracuse received an honorarium from Jazz Pharmaceuticals for a speaking engagement.)
Originally released July 17, 2001; last updated September 10, 2018; expires September 10, 2021

Overview

Psychiatric disorders associated with anxiety and autonomic arousal, such as trauma-based disorders and anxiety disorders, are well known to be associated with a variety of sleep complaints, most commonly insomnia and nightmares. A review of trauma-based disorders such as posttraumatic stress disorder (PTSD) and anxiety disorders, including generalized anxiety disorder (GAD), panic disorder, and specific and social phobia are provided, along with typical subjective and objective sleep profiles. In this article, the author discusses the bidirectional relationship between anxiety symptoms and sleep and highlights studies examining the role of sleep disturbances in the development and exacerbation of such disorders, particularly posttraumatic stress disorder.

Key points

 

• Insomnia and nightmares are hallmarks of posttraumatic stress disorder, and sleep disturbances are associated with the severity of symptoms and the likelihood of symptom remission at follow-up. By contrast, sleep problems are less common in social and specific phobias.

 

• The management of insomnia in the context of mental disorders rests in large part on successful treatment of the primary condition, particularly in the case of generalized anxiety disorder. Residual sleep problems following treatment are common in posttraumatic stress disorder and panic disorder and will often warrant independent treatment. Sleep-focused therapies only minimally improve anxiety symptoms in patients with and without accompanying anxiety disorders.

 

• Coadministration of anxiety- and sleep-focused pharmacotherapies in patients with both anxiety and sleep disturbances may yield greater resolution of anxiety symptoms than monotherapy for anxiety disorders.

 

• Nonmedication approaches targeting nightmares in patients with posttraumatic stress disorder have demonstrated benefit in uncontrolled trials but require more rigorous controlled evaluations in different patient populations.

Historical note and terminology

The first attempt at a systematic descriptive approach to anxiety and trauma was provided by Freud, who described a distinct syndrome "anxiety neurosis" (Freud 1957). Further attempts at systematic classification of anxiety disorders occurred with the first edition of the Diagnostic and Statistical Manual of Mental Disorders in 1952, followed by a second edition in 1968 that was based on "the best clinical judgment and experience" of a committee and consultants, often utilizing unproved mechanisms in their classification schemes. A move toward a more descriptive classification "validated primarily by follow-up and family studies" was introduced in an article titled “Diagnostic Criteria for Use in Psychiatric Research” (Feighner et al 1972). This work formed the basis for the development of the third and fourth editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM) (Uhde 2000). Anxiety disorders were defined broadly and included posttraumatic stress disorder along with obsessive-compulsive disorder, as well as “insomnia second to anxiety disorder.”

In the 2013 fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, trauma-based disorders and obsessive-compulsive disorders were removed from anxiety disorders and given their own designation, reflecting differences in phenotype as well as etiology, despite common subjective complaints of “anxiety” (American Academy of Sleep Medicine 2014). The condition “insomnia secondary to anxiety disorder” was replaced with “insomnia disorder,” which can specify if occurring with a comorbid psychiatric disorder.

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