Mar 22, 2017
Alzheimer disease linked to the metabolism of unsaturated fats
A new study published in PLOS Medicine's Special Issue on Dementia has found that the metabolism of omega-3 and omega-6 unsaturated fatty acids in the brain are associated with the progression of Alzheimer disease.
Mar 16, 2017
Cause of obsessive-compulsive disorder discovered
German researchers show in mouse models that the absence of the protein SPRED2 alone can trigger excessive grooming behavior. This protein absence increases the activity of the Ras/ERK-MAP kinase cascade, leading to obsessive compulsive symptoms.
Mar 13, 2017
Never before seen images of early stage Alzheimer disease
Researchers at Lund University have used the MAX IV synchrotron to produce images that predate the formation of of beta-amyloid plaques. They reveal that beta-amyloid is not a single peptide, but instead a tetramer. This suggests that instead of attempting to eliminate beta-amyloid, it should be stabilized.
Mar 10, 2017
Rapid blood pressure drops in middle age linked to dementia in old age
Middle-aged people who experience orthostatic hypotension may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests. The findings suggest that orthostatic hypotension may cause lasting damage, possibly because it reduces needed blood flow to the brain.
Mar 07, 2017
New analysis reveals 24 compounds that can help reduce impact of harmful proteins in the brain
A study by Indiana University researchers has identified 24 compounds--including caffeine--with the potential to boost an enzyme in the brain--NMNAT2--shown to protect against dementia. The new study appears today in the journal Scientific Reports.
Feb 23, 2017
Sugar’s ‘tipping point’ link to Alzheimer disease revealed
For the first time a "tipping point" molecular link between the blood sugar glucose and Alzheimer disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer disease -- MIF (macrophage migration inhibitory factor). The study is published in the journal Scientific Reports.
Feb 16, 2017
Postmenopausal hormone therapy exceeding ten years may protect from dementia
Postmenopausal estrogen-based hormone therapy lasting longer than 10 years was associated with a decreased risk of Alzheimer disease in a large study carried out at the University of Eastern Finland. The study also found long-term use of hormonal replacement therapy was associated with a better performance in certain cognitive domains, namely global cognition and episodic memory.
Feb 14, 2017
Children of patients with C9orf72 mutations at greater risk of frontotemporal dementia / ALS
Researchers have demonstrated that if an affected parent passes on the C9orf72 mutation, the children will be affected at a younger age than the parent. There are no indications that the disease progresses more quickly. These results are published today in JAMA Neurology.
Feb 10, 2017
Gut bacteria may play a role in Alzheimer disease
New research from Lund University in Sweden has shown that intestinal bacteria can accelerate the development of Alzheimer disease. The study in mice revealed a direct causal link between gut bacteria and beta-amyloid plaque in the brain. The results open up the door to new opportunities for preventing and treating the disease.
Jan 30, 2017
Researchers find mental activities may protect against mild cognitive impairment
Mayo Clinic researchers have found that engaging in mentally stimulating activities, even late in life, may protect against new-onset mild cognitive impairment. The study found that computer use had the biggest benefit. The results are published in the January 30 edition of JAMA Neurology.