Jul 14, 2017
Patients receiving eculizumab at high risk for invasive meningococcal disease despite vaccination
Some patients receiving eculizumab who were vaccinated with the recommended meningococcal vaccines still developed meningococcal disease. Of important note, eculizumab is currently under US FDA review as potential treatment for patients with generalized myasthenia gravis who are AChR antibody-positive.
Mar 23, 2017
Researchers develop first-of-a-kind model to research post-malaria epilepsy
A first-of-its-kind mouse model could lead to an understanding of how cerebral malaria infection leads to the development of epilepsy in children, and to the prevention of seizures. The model was developed by Penn State researchers and their results are published in Scientific Reports.
Mar 14, 2017
Immune molecule protects against Zika virus infection in animal models
A molecule naturally produced by the immune system, 25-hydroxycholesterol, protects mice and monkeys against Zika virus infection, an international team of researchers has found. It also protects against Zika-induced microcephaly.
Feb 28, 2017
Study finds no evidence of common herpes type virus in aggressive brain cancer tissue
In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say they have found no evidence of cytomegalovirus infection and conclude that a link between the 2 diseases, as claimed by earlier reports, likely does not exist.
Feb 21, 2017
Zika may cause miscarriages, thin brain tissue in babies carried to term
Using unique mouse model, Johns Hopkins researchers believe they can develop treatment or vaccine targets in order to fight the virus. The study findings were published today in Nature Communications.
Feb 17, 2017
Scientists uncover how Zika virus causes microcephaly
A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered the mechanisms that the Zika virus uses to alter brain development. These findings are detailed in Stem Cell Reports.
Feb 02, 2017
New Zika vaccine candidate protects mice and monkeys with a single dose
A new Zika vaccine candidate has the potential to protect against the virus with a single dose, according to a research team led by scientists from the Perelman School of Medicine at the University of Pennsylvania.
Jan 10, 2017
Researchers develop new compound to fight cytomegalovirus
A Retro94-based compound may prevent human cytomegalovirus from reproducing and help to protect immunocompromised patients, reports a study by Penn State researchers published in the Journal of Virology.
Dec 16, 2016
Study finds link between HIV treatment and neuronal degeneration
Researchers have pinpointed some of the key players in causing neuronal damage. Their work suggests that certain protease inhibitors lead to the production of the peptide beta amyloid. Notably, inhibiting the enzyme BACE1 protected human and rodent brain cells from harm, suggesting that targeting this pathway with a new drug could minimize damage to neurons in patients on antiretroviral therapies.
Dec 09, 2016
Scientists develop new mouse model to study meningitis
NIH scientists have established a new mouse model to study meningitis caused by Salmonella. They plan to use the model to determine how Salmonella Typhimurium infects and causes damage in the brain, including which immune cells are involved. They will also study potential treatments to prevent Salmonella from gaining access to the CNS.