May 15, 2017
Neurosurgeons perform focused ultrasound treatment for essential tremor
MR-guided focused ultrasound treatment, now FDA approved, has great promise as a non-invasive treatment for essential tremor. In this instance, the patient is now tremor-free in his right hand post-procedure, after 10 years of suffering from bilateral essential tremor.
May 04, 2017
In Huntington disease, traffic jams in the nucleus kill neurons
Working with mouse, fly, and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of the nucleus appear to be a direct cause of brain cell death in Huntington disease.
May 03, 2017
Antibiotic doxycycline may offer hope for treatment of Parkinson disease
A study published in Scientific Reports suggests that doxycycline, an antibiotic used for over half a century against bacterial infections, can be prescribed at lower doses for the treatment of Parkinson disease. According to the authors, the substance reduces the toxicity of α-synuclein.
Apr 20, 2017
150-year-old drug may provide ‘off’ time relief for people with advanced Parkinson disease
A study that will be presented at the American Academy of Neurology’s 69th Annual Meeting in Boston next week found that advanced Parkinson disease patients who were given the drug apomorphine had a significantly greater reduction of “off” time than those who were given placebo.
Apr 10, 2017
Cause dystonia discovered
Researchers at the University of Liverpool have identified mutations in the gene encoding a protein known as hippocalcin as one cause of dystonia. These findings provide a clue toward the development of a potential new treatment
Mar 06, 2017
Extended use of MAO-B inhibitors slows decline in Parkinson disease patients
In a retrospective analysis published in the Journal of Parkinson's Disease, researchers looked at the results from a large study, the NET-PD-LS1 clinical trial, and found that participants who received an MAO-B inhibitor for a longer period of time experienced slower clinical decline.
Mar 02, 2017
‘Red hair’ gene variant may underlie association between melanoma and Parkinson disease
In the March issue of Annals of Neurology Massachusetts General Hospital investigators report that mice carrying the red hair variant of the melanocortin 1 receptor (MC1R) gene have reduced production of the neurotransmitter dopamine in the substantia nigra and are more susceptible to toxins known to damage those neurons.
Feb 15, 2017
Neurotrophic factor GDNF is an important regulator of dopamine neurons in the brain
In an article published in the Journal of Neuroscience, University of Helsinki researchers establish that GDNF is an important physiological regulator of the functioning of the brain's dopamine neurons. This knowledge is crucial for developing new treatments for diseases associated with some type of disorder in the function of the dopamine neurons, and specifically in the dopamine transporter.
Feb 13, 2017
Cellular quality control process could be Huntington disease drug target
A Duke-led team found that the master control for chaperone production, called HSF1, was being destroyed in Huntington disease due to the presence of abnormally high levels of the chemical modifier CK2. As a result, neurons die due to their inability to produce sufficient levels of the beneficial chaperones.
Dec 30, 2016
For welders, Parkinson-like symptoms get worse with exposure
Welders can develop Parkinson disease-like symptoms that may get worse the longer and more they are exposed to the chemical element manganese from welding fumes, according to a study published in the December 28, 2016, online issue of Neurology.®