Mar 06, 2017
Extended use of MAO-B inhibitors slows decline in Parkinson disease patients
In a retrospective analysis published in the Journal of Parkinson's Disease, researchers looked at the results from a large study, the NET-PD-LS1 clinical trial, and found that participants who received an MAO-B inhibitor for a longer period of time experienced slower clinical decline.
Mar 02, 2017
‘Red hair’ gene variant may underlie association between melanoma and Parkinson disease
In the March issue of Annals of Neurology Massachusetts General Hospital investigators report that mice carrying the red hair variant of the melanocortin 1 receptor (MC1R) gene have reduced production of the neurotransmitter dopamine in the substantia nigra and are more susceptible to toxins known to damage those neurons.
Feb 15, 2017
Neurotrophic factor GDNF is an important regulator of dopamine neurons in the brain
In an article published in the Journal of Neuroscience, University of Helsinki researchers establish that GDNF is an important physiological regulator of the functioning of the brain's dopamine neurons. This knowledge is crucial for developing new treatments for diseases associated with some type of disorder in the function of the dopamine neurons, and specifically in the dopamine transporter.
Feb 13, 2017
Cellular quality control process could be Huntington disease drug target
A Duke-led team found that the master control for chaperone production, called HSF1, was being destroyed in Huntington disease due to the presence of abnormally high levels of the chemical modifier CK2. As a result, neurons die due to their inability to produce sufficient levels of the beneficial chaperones.
Dec 30, 2016
For welders, Parkinson-like symptoms get worse with exposure
Welders can develop Parkinson disease-like symptoms that may get worse the longer and more they are exposed to the chemical element manganese from welding fumes, according to a study published in the December 28, 2016, online issue of Neurology.®
Nov 22, 2016
Novel type of cell death in Huntington disease may lead to effective new therapies
Researchers centered at Tokyo Medical and Dental University identified a novel type of cell death associated with mutant huntingtin, which they called ballooning cell death. These cells gradually expanded like a balloon, until they ruptured.
Nov 01, 2016
Combined training may prevent falls associated with Parkinson disease and other disorders
A combination of virtual reality and treadmill training may prove effective in preventing dangerous falls associated with aging, Parkinson disease, mild cognitive impairment, or dementia, according to a new Tel Aviv University-Tel Aviv Sourasky Medical Center study published in The Lancet.
Oct 26, 2016
Understanding essential tremor
International researchers have found a strong correlation between essential tremor and a gene known as STK32B. They also found 2 other genes correlated to a lesser extent with the disease. The findings are published in the current edition of Brain.
Oct 18, 2016
Scientists develop MRI-guided neural stem cell delivery method
Scientists develop an operational technique for delivering stem cells with low invasiveness and high accuracy in placement of stem cells to the basal ganglia, moving forward stem cell therapies to treat neurologic disorders.
Sep 30, 2016
Caffeine-based compounds show promise against Parkinson disease
A team of researchers from the University of Saskatchewan has developed 2 caffeine-based chemical compounds that show promise in preventing the ravages of Parkinson disease. The team’s findings are published in the journal ACS Chemical Neuroscience.