Neuro-Oncology News

May 24, 2017
‘Sticky’ particles promise more precise drug delivery for brain cancer
A Yale research team has found that by tinkering with the surface properties of drug-loaded nanoparticles, they can potentially direct these particles to specific cells in the brain. Their findings are published in Nature Communications.
Apr 14, 2017
Glioblastoma patients may benefit from a vaccine-chemotherapy combination
A study led by Duke Unversity researchers, published in Clinical Cancer Research, finds that a vaccine targeting cytomegalovirus antigen pp65, combined with high-dose chemotherapy (temozolomide), improved both progression-free survival and overall survival for a small group of glioblastoma patients.
Feb 28, 2017
Study finds no evidence of common herpes type virus in aggressive brain cancer tissue
In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say they have found no evidence of cytomegalovirus infection and conclude that a link between the 2 diseases, as claimed by earlier reports, likely does not exist.
Feb 27, 2017
Molecule stops fatal pediatric brain tumor
Northwestern Medicine scientists have found a molecule that stops the growth of diffuse intrinsic pontine glioma inmice. The study, using a mouse model, is published today in Nature Medicine.
Jan 11, 2017
Tumor-seeking salmonella treats brain tumors
Biomedical engineers at Duke University have recruited Salmonella typhimurium in the fight against glioblastoma. Tests in rat models with extreme cases of the disease showed a remarkable 20% survival rate over 100 days -- roughly equivalent to 10 human years -- with the tumors going into complete remission.
Nov 17, 2016
Study reveals new information about how glioblastoma multiforme spreads
A study by MD Anderson Cancer Center researchers has established that the gene WNT5A is a key factor in glioma stem cells transitioning to GdECs. This opens up the possibility for a new therapeutic strategy for patients with glioblastoma.
Sep 15, 2016
Computer program beats physicians at brain cancer diagnosis
A program developed at Case Western Reserve was nearly twice as accurate as 2 neuroradiologists in determining whether abnormal tissue seen on MRI was radiation necrosis or if brain cancer had returned. The findings could speed identification of recurrent tumors, and eliminate costly and risky brain biopsies.
Mar 14, 2016
Anticancer drug restores hearing in some patients with neurofibromatosis
In a small clinical study with an anticancer drug that halts blood vessel growth, intravenous bevacizumab, a handful of people with neurofibromatosis type 2 and hearing loss had restoration of hearing. Results of the collaborative study were described online March 14, 2016 in the Journal of Clinical Oncology.
Mar 03, 2016
PGK1 protein promotes brain tumor formation and cancer metabolism
PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.
Feb 19, 2016
Biochemical alteration responsible for brain tumor resistance identified
A team of researchers have observed that the cells in glioblastoma tumors harbor a common intrinsic defect, related to the enzyme endonuclease DFF40/CAD, that prevents them from degrading their genetic material during apoptosis. This lack of degradation and removal of genetic material from malignant cells could have detrimental consequences for the organism, such as new tumor processes, often more aggressive than the original one.
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