Dr. Pruitt of the University of Pennsylvania School of Medicine has no relevant financial relationships to disclose.)
This article includes discussion of Crohn disease: neurologic manifestations, regional enteritis, and granulomatous colitis. The foregoing terms may include synonyms, similar disorders, variations in usage, and abbreviations.
Crohn disease is an inflammatory bowel disease that predominantly involves the terminal ileum and colon. However, a wide range of extraintestinal complications may also compose a portion of the clinical picture. Extraintestinal manifestations may precede the onset of gastrointestinal symptoms by several years. Neurologic disorders associated with inflammatory bowel disease are reported in 3% of patients, but they often represent an important cause of morbidity as well as a diagnostic challenge. Besides the disease itself, the increasing use of immunosuppressant and other therapies may also play a crucial role in the development of neurologic disorders of different types and pathogenesis. Virtually all components of the nervous system, both central and peripheral, may become involved. Vigilance in recognizing neurologic dysfunction in the setting of Crohn disease, with prompt institution of appropriate treatment, can be important in avoiding irreversible consequences.
• Crohn disease is one of the inflammatory diseases that predominantly involve the gastrointestinal system, especially the terminal ileum and colon.
• A wide range of extraintestinal complications may compose a portion of the clinical picture. Neurologic dysfunction is an infrequent but potentially devastating extraintestinal manifestation of Crohn disease. Virtually all components of the nervous system, both central and peripheral, may become involved.
• Vigilance in recognizing neurologic dysfunction in the setting of Crohn disease, with prompt institution of appropriate treatment, can be important in avoiding irreversible consequences.
Historical note and terminology
Crohn, Ginzburg, and Oppenheimer pooled their experiences and described a condition they termed “terminal ileitis” (Crohn et al 1932). Colonic involvement was later recognized, prompting a renaming of the process as “regional enteritis” or “granulomatous enterocolitis.” However, it has become customary to use the eponymous designation, “Crohn disease.”
Earlier descriptions of what probably was Crohn disease can be found. Ulcerative colitis and Crohn disease are the most widely recognized members of a group of conditions collectively labeled inflammatory bowel disease. Despite many similarities, the clinical features and pathological profiles of the 2 conditions also demonstrate decided differences (Table 1). Neurologic dysfunction has been described in both. However, the focus in this article will be specifically on Crohn disease and its neurologic complications.
Table 1. Gastrointestinal Features of Inflammatory Bowel Disease
• Exacerbations and remissions typical
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