Decompression sickness: neurologic manifestations

K K Jain MD (Dr. Jain is a consultant in neurology and has no relevant financial relationships to disclose.)
Originally released April 21, 1998; last updated February 10, 2020; expires February 10, 2023

This article includes discussion of neurologic manifestations of decompression sickness, neurologic complications of decompression sickness, Caisson disease, and decompression illness. The foregoing terms may include synonyms, similar disorders, variations in usage, and abbreviations.


Divers who have experienced pressures greater than 2 atmospheres absolute may develop decompression sickness if they ascend too rapidly. Decompression sickness may be mild, with only limb and joint pain ("bends," type 1), or serious, with neurologic and pulmonary manifestations (type 2). Most serious are symptoms of medullary involvement with development of paraparesis. Divers with a patent foramen ovale are more liable to develop decompression sickness than divers without a patent foramen ovale. Treatment in a pressure chamber is essential for recovery, and detailed decompression tables are used to prevent decompression sickness.

Key points


• Decompression sickness usually occurs during rapid ascent from depth after diving but may also occur in rapid ascent to high altitudes from sea level.


• Systemic manifestations may involve the nervous system.


• Decompression sickness can be avoided by gradual ascent, and if it occurs, it is treated by hyperbaric recompression.


• Hyperbaric oxygen has been found to be useful in treating decompression sickness with neurologic manifestations.

Historical note and terminology

Decompression sickness is one of several dysbarisms, ie, disturbances in the human body resulting from a change in atmospheric pressure. Divers and compressed air tunnel workers have experienced that if they adjust too quickly to the normal environmental pressure, they will develop a variety of unpleasant symptoms, and that these can be prevented by a slower ascent or by hyperbaric recompression. Rapid ascent to high altitudes in an aircraft with an uncompressed cabin can produce similar symptoms. The first and least severe symptoms are characterized by limb and joint pain. Thereafter, or with more rapid ascent or decompression, other nervous system symptoms will occur.

The condition was well known among miners and tunnel workers, and it was, therefore, called "caisson disease." Other terms used to describe the condition are "the bends" (limb and joint pain), "the chokes," and "hits."

The content you are trying to view is available only to logged in, current MedLink Neurology subscribers.

If you are a subscriber, please log in.

If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services. Site license users, click the Site License Acces link on the Homepage at an authorized computer.

If you have never registered before, click Learn More about MedLink Neurology  or view available Service Plans.

Find out how you can join MedLink Neurology