K K Jain MD (

Dr. Jain is a consultant in neurology and has no relevant financial relationships to disclose.

Originally released June 30, 1999; last updated November 2, 2020; expires November 2, 2023

Historical note and terminology

Fluoxetine is a selective serotonin reuptake inhibitor. Serotonin, or 5-hydroxytryptamine, was discovered in 1948 and since then has played an increasing part in the understanding of human diseases, particularly those involving the nervous system (Rapport et al 1948). Demonstration of pharmacological manipulation to prevent selective reuptake led to the synthesis of fluoxetine for the treatment of depression (Wong et al 1974). It was introduced in 1988. The development of selective serotonin reuptake inhibitors was a major achievement in pharmacologic manipulation of this system. The use of fluoxetine has expanded to include other disorders as well.

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