Historical note and terminology
The era of antiepileptic drugs started with the introduction of bromides in 1857 and was followed by the discovery of the anticonvulsant effect of barbiturates in 1912. Hydantoins, structurally like barbiturates, followed as second generation antiepileptic agents. The main action of hydantoins is to prevent the spread of seizure activity by stabilizing the neuronal membranes through modulating ion fluxes. Phenytoin (diphenylhydantoin) was synthesized in 1908 (Biltz 1908) and was introduced in the treatment of epilepsy in 1938 (Merritt and Putnam 1938).
The content you are trying to view is available only to logged in, current MedLink Neurology subscribers.
If you are a subscriber, please log in.
If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services. Site license users, click the Site License Acces link on the Homepage at an authorized computer.