K K Jain MD (Dr. Jain is a consultant in neurology and has no relevant financial relationships to disclose.)
Originally released January 30, 2003; last updated January 21, 2020; expires January 21, 2023

Historical note and terminology

Antipsychotics have been used for decades for the treatment of schizophrenia. Conventional drugs included central dopamine receptors such as chlorpromazine and haloperidol. Atypical antipsychotics (clozapine and risperidone) have been introduced in recent years and are more effective, and in addition to acting as dopamine receptor antagonists, they are relatively potent 5-HT2A antagonists. Atypical antipsychotics have fewer side effects than conventional antipsychotics. In addition, they have applications in nonpsychotic neurologic disorders.

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