Rapid eye movement sleep behavior disorder
Under nonpathological circumstances, REM sleep is characterized by an activated brain state in combination with skeletal muscle paralysis. This paradox, wake-like brain activity combined with flaccid motor function, prevents the enactment of dream activity. In REM sleep behavior disorder (RBD), REM sleep atonia is lost and patients act out dream mentation. The majority of patients with spontaneously occurring RBD will eventually demonstrate signs and symptoms of neurodegenerative disorders, most commonly one of the synucleinopathies.
Jun. 22, 2021