Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

VLA-4 changes similar to a jackknife

VLA-4 changes affinity with conformational changes similar to a jackknife. (From: Chigaev A, Zwartz GJ, Buranda T, Edwards BS, Prossnitz ER, Sklar LA. Conformational regulation of alpha4, beta1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation. J Biol Chem 2004;279(31):32435-43.)

Related Media

Associated Disorders

  • AIDS
  • CNS lymphoma
  • autoimmune diseases
  • leukemia
  • progressive multifocal leukoencephalopathy
  • tuberculosis