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VLA-4 changes similar to a jackknife

VLA-4 changes affinity with conformational changes similar to a jackknife. (From: Chigaev A, Zwartz GJ, Buranda T, Edwards BS, Prossnitz ER, Sklar LA. Conformational regulation of alpha4, beta1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation. J Biol Chem 2004;279(31):32435-43.)