Movement Disorders
Dopa-responsive dystonia
Jul. 18, 2023
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
Nearly 3,000 illustrations, including video clips of neurologic disorders.
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In the cytoplasm, vitamin B12 deficiency impacts the enzyme methionine synthase (MTR). This deficiency not only disrupts the biosynthesis of crucial compounds but also triggers the accumulation of reaction intermediates that are potentially toxic at increased concentrations, leading to metabolic decompensation. Lightning bolt icons indicate the metabolic steps that might indirectly contribute to oxidative stress. The light green arrows highlight further biochemical implications resulting from vitamin B12 deficiency, potentially influencing molecular and cellular processes. (Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)