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(A) Lateral projection of distal basilar artery occlusion. (B) Anteroposterior projection of distal basilar artery occlusion. (Contributed by Dr. Jeffrey Saver.)
Jan. 12, 2021
Neuro-Ophthalmology & Neuro-Otology
Leber hereditary optic neuropathy is a disease caused by various mutations in the mitochondrial genome and, as such, is inherited only via the maternal ovum as spermatozoa do not have mitochondria. It usually manifests as sequential binocular acute painless vision loss in sons of carrier mothers. The typical vision loss pattern is decreased visual acuity, with most patients seeing 20/200 or worse, a visual field defect involving the blind spot, and central fixation (cecocentral scotoma).
Dec. 19, 2020
Mar. 03, 2020
Transverse myelitis is part of a spectrum of demyelinating disease but has unique features that differentiate it from multiple sclerosis. The spinal cord damage in acute complete transverse myelitis generally affects all cord functions, and the symptoms are typically more severe than in typical cord lesions of multiple sclerosis. The first symptoms in transverse myelitis are ascending paresthesias or back pain at the level of the myelitis, plus leg weakness and sphincter dysfunction. Tingling or paresthesias in the feet soon progress to loss of pain, temperature, and vibration sensation, and then halt at a sensory level, usually thoracic (approximately 80%).
Aug. 05, 2016
Neurologic involvement of Behcet disease appears as a vascular-inflammatory CNS disease with focal or multifocal parenchymal involvement. A less common form includes isolated cerebral venous sinus thrombosis and intracranial hypertension. Behcet's is characterized by oral or genital ulcers, eye inflammation, and skin lesions.
Sep. 01, 2020
Leukemia is defined as a group of neoplasms characterized by circulating malignant cells arising from granulocytic or lymphoid precursors. Direct effects of leukemia on the nervous system include parenchymal, skull base, and meningeal metastases. Indirect effects of leukemia on the nervous system include cerebrovascular complications, such as stroke or hemorrhage from hyperviscosity syndromes, and infection or other iatrogenic complications.
Mar. 20, 2018
Aug. 17, 2019
Headache & Pain
Orofacial and cephalic pain can arise from a variety of conditions that affect the nerves that supply the head, their roots, and other pain-sensitive structures. Trigeminal neuralgia, the prototypical cephalic neuralgia, is characterized by bursts of excruciating facial pain in the distribution of one or more branches of the trigeminal nerve. Cranial neuralgias may be secondary to central nervous system or peripheral pathology, including carotid artery dissection, arterial venous malformations, and aneurysmal dilatation with subsequent compression.
Jan. 18, 2021