Neuropharmacology & Neurotherapeutics
Oct. 04, 2021
Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
In hepatorenal tyrosinemia, the cytosolic enzyme porphobilinogen synthase (ALA dehydratase, aminolevulinate dehydratase), top right of figure, is strongly inhibited by succinylacetone, producing an accumulation of δ-aminolevulinic acid (δ-ALA, dALA), which is excreted in the urine, and the development of porphyria-like neurologic crises. (Courtesy of Wikimedia Commons. Creative Commons Attribution-ShareAlike License.)