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Paraneoplastic neuropathy (1)

(A) H and E stained section showing diffuse infiltration of the endoneurium with multiple lymphocytes (arrow). In addition, there is loss of fibers and some myelin degeneration. (B) LFB stained section showing myelinated axons from control sural nerve. (C) Section showing degeneration of predominantly large myelinated axons (arrow) in paraneoplastic neuropathy. (Contributed by Dr. James W Russell.)

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Associated Disorders

  • Acute panautonomic neuropathy
  • Botulism
  • Connective tissue disease
  • Guillain-Barré syndrome
  • Lambert-Eaton myasthenic syndrome
  • Mixed connective tissue disease
  • Porphyria
  • Rheumatoid arthritis
  • Sjogren syndrome
  • Sjögren syndrome
  • Systemic lupus erythematosus