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A muscle biopsy showing the typical appearance of rod bodies on light microscopy (modified Gomori trichrome stain; x400). (Contributed by Dr. Susan Iannaccone.)
Jul. 02, 2020
Neuropharmacology & Neurotherapeutics
Aug. 10, 2020
Feb. 15, 2021
Metabolic encephalopathy involves global cerebral dysfunction, with presentations ranging from mild executive dysfunction to deep coma. Delirium is often the initial phase of impairment of consciousness, with impairment of attention, fluctuations in alertness, clouding of consciousness, disturbances in the wake-sleep cycle, and sometimes agitation and restlessness. Selective attention and the ability to process information are the cognitive domains primarily affected.
Jan. 31, 2021
Jan. 19, 2021
Behavioral & Cognitive Disorders
Alzheimer disease (AD) is a neurodegenerative disease that causes dementia, most often starting with memory loss. Its hallmark microscopic features are neurofibrillary tangles and amyloid plaques. Other symptoms may include anomia, visuospatial deficits, executive dysfunction, apathy, depression, and agitation.
Feb. 19, 2020
Peripheral neurolymphomatosis is a rare neurologic manifestation of non-Hodgkin lymphoma in which peripheral nerve infiltration of lymphoma cells is a dominant feature both clinically and pathologically. Affected neural structures include peripheral nerves, spinal nerve roots, cranial nerves, and plexus, commonly with multiple site involvement. Neurolymphomatosis is also reported as a relapse of intravascular large B-cell lymphoma.
Feb. 25, 2021
Epilepsy & Seizures
In this update, the author provides an overview on the prevalence of familial mesial temporal lobe epilepsy and its clinical presentation in kindreds
Mar. 29, 2021