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Schematic representation of the clinical aspects of Niemann-Pick C disease. (Modified from: Vanier MT. Niemann-Pick disease type C. Orphanet J Rare Dis 2010;5:16.)
Jul. 02, 2020
Progressive systemic sclerosis is a condition associated with thickening of the skin and tethering to subcutaneous tissues as well as smooth muscle atrophy and fibrosis of internal organs such as the gastrointestinal tract, lungs, heart, and kidneys. Pain symptoms are common in patients with systemic sclerosis and are independently associated with more frequent episodes of Raynaud phenomenon, active ulcers, and worsening synovitis.
Apr. 24, 2021
General Child Neurology
Apr. 20, 2020
Advanced sleep-wake phase disorder is characterized by habitual sleep-wake times advanced in relation to conventional or socially acceptable time and is present for at least 3 months. Symptoms include evening sleepiness, early sleep onset, and early morning awakenings. Several mutations in clock genes have been identified in familial cases. This is the first hereditary circadian rhythm variant described in humans.
Mar. 28, 2021
Insomnia appears in several forms: (1) difficulty initiating sleep, (2) repeated or lengthy awakenings, (3) early awakenings, (4) inadequate total sleep time, or (5) poor quality of sleep as reflected by its consequences, including daytime sleepiness. The ICSD-3 defines 3 different classification systems for insomnia: chronic insomnia disorder, short-term insomnia disorder, and other insomnia disorder. Complications of insomnia include impaired responses to infections, increase in inflammation, higher levels of the stress hormone cortisol, and other biomarkers related to fatigue and poor health.
Oct. 11, 2020
Neuropharmacology & Neurotherapeutics
Nov. 03, 2020
Mar. 16, 2021
Neuroethics is a distinct content field that is concerned with "the ethics of neuroscience and the neuroscience of ethics." In clinical
Mar. 28, 2018