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The normal handwriting sample demonstrates the effectiveness of D-penicillamine therapy. (Contributed by Dr. Hugo Moser.)
Neuropharmacology & Neurotherapeutics
Mar. 06, 2021
Headache & Pain
Headache is usually the first and most frequently encountered symptom in intracranial infection, and remits with resolution of the infection in most cases. It may result from the meningeal inflammation, increased intracranial pressure, or a mass effect producing traction on pain-sensitive intracranial structures.
Oct. 27, 2020
Aug. 24, 2020
Jul. 26, 2021
Epilepsy & Seizures
In this article, the authors present recent data and discussion about the causes, syndromes, diagnosis, and management of hypermotor seizures.
Jan. 18, 2021
Childhood Degenerative & Metabolic Disorders
Pelizaeus-Merzbacher disease and the allelic disorder spastic paraplegia 2 (SPG2) are hereditary leukodystrophies caused by mutations of the PLP1 gene. The nature of the mutation plays an important role in determining the cellular effects on oligodendrocytes, disease severity, and pattern of inheritance. The clinical syndromes range from the severe connatal Pelizaeus-Merzbacher disease syndrome, characterized by congenital hypotonia, nystagmus, and stridor, to an uncomplicated spastic paraparesis syndrome.
Dec. 26, 2019
Neuro-Ophthalmology & Neuro-Otology
Sixth nerve palsy often presents with binocular horizontal diplopia, worse in the field of action of the paretic lateral rectus muscle. Ischemia, head trauma, and compression by a mass lesion are the most common causes in adults.
Jan. 12, 2000
Stroke & Vascular Disorders
Until recently, the only FDA-approved treatment for acute ischemic stroke was intravenous rtPA given within 4.5 hours of stroke onset. New mechanical thrombectomy techniques have greatly improved recanalization rates for patients with acute ischemic strokes caused by intracranial large vessel occlusion. Multiple randomized, controlled trials have demonstrated the efficacy and superiority of mechanical thrombectomy over standard medical care in carefully selected acute ischemic stroke patients.
Apr. 15, 2021