Megalencephaly in Alexander disease (infantile type)

This 22-month-old girl has an enlarged head with frontal bossing. (Reprinted with permission. Johnson AB. Alexander disease. In: Moser HW, editor. Neurodystrophies and neurolipidoses. Handbook of clinical neurology. Vol. 66, revised series vol. 22. Amsterdam: Elsevier, 1996:701-10.)