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Dynamic changes in Tay-Sachs disease

(a) Dynamic changes in the HexA activity in the TSD patient’s plasma after UCBCT and curcumin administration; normal level of HexA activity observed in healthy donors is 24–148 nmol/mL/h; (b) Dynamic changes in the HexA concentration in the TSD patient’s serum after UCBCT and curcumin administration. The HexA concentration range measured in a cohort of healthy donors (n = 10) is shown in gray; (c) Dynamic changes in the GM2 level in the TSD patient’s plasma after UCBCT and curcumin administration. The GM2 level range measured in a cohort of healthy donors (n = 10) is shown in gray. The patient took curcumin for 3 months as follows: 500 mg/day for 10 days, 1000 mg/day for 10 days and then 3500 mg/day for 100 days. The graph represents the mean and standard deviation of three technical replicates of each patient point and the mean and standard deviation of one technical replicate of ten healthy donors (ten biological replicates). Statistical analysis was achieved using GraphPad Prism 7 software (GraphPad Software), with one-way ANOVA followed by Tukey’s HSD post hoc comparison test.

Credit: Kazan Federal University