Artificial neural connection allows new cortical site to control hand movements

Jan 07, 2020

Restoration of lost motor function after stroke is typically accomplished after strenuous rehabilitation therapy lasting for over months. However, new research published by a group led by Yukio Nishimura, the project leader of the Neural Prosthesis Project, Tokyo Metropolitan Institute of Medical Science showed that an artificial neural connection successfully allowed a new cortical site, previously unassociated with hand movements, to regain control of a paralyzed hand in a matter of minutes.

In this research, experimental animals regained voluntary control of a paralyzed hand about 10 minutes after establishment of an artificial neural connection. Animals engaged in learning with a functional artificial neural connection showed variable levels of input signals provided by the cerebral cortex as hand movement improved. Specifically, the activated area of the cortex became more focused as control of hand movements improved.

Through this training of various areas of the cerebral cortex, the research team successfully imparted a new ability to control paralyzed hands via an artificial neural connection, even if those areas were not involved in hand control prior to the stroke. Examples of such regions include areas of the cortex that control the movement of other body parts such as the face or shoulder, and even the somatosensory cortex, which is responsible for tactile and proprioception processing and is normally not associated with motor control. This finding suggests that an artificial neural connection can impart new motor control functions to any cortical region.

This research will contribute to the development of innovative therapies that will help stroke patients regain lost motor function by imparting this function to regions of the cerebral cortex previously not associated with hand movement. It is expected that these therapies will have practical clinical applications beyond restoring motor function and lead to the development of novel techniques to further integrate human brains with computers. The researchers will continue to investigate whether extended use of an artificial neural connection will enhance the activity of spared neural networks and facilitate functional recovery so that patients will be able to regain voluntary control of paralyzed body parts even if they discontinue using the artificial neural connection.

Source: News Release
Tokyo Metropolitan Institute of Medical Science
January 7, 2020