COVID-19 infection may be part of a “perfect storm” for Parkinson disease

Oct 23, 2020

Can COVID-19 infection increase the risk of developing Parkinson disease?

That's the question posed by a new commentary published in the journal Trends in Neurosciences, which explores three known case studies of people developing Parkinson disease-like symptoms in the weeks following infection with SARS-CoV-2, the virus that causes COVID-19. While rare, these cases provide important insights into potential long-term implications of infections.

The commentary was co-authored by Patrik Brundin MD PhD of Van Andel Institute, Avindra Nath MD of the National Institute of Neurological Disorders and Stroke of the National Institutes of Health, and J David Beckham MD of University of Colorado.

"As we continue to grapple with the COVID-19 pandemic today, we also must consider its implications for the future," Brundin said. "Evidence is mounting that the side effects of COVID-19 infection, such as inflammation and damage to the vascular system, could lay the foundation for development of Parkinson disease. COVID-19 is clearly a major and ongoing public health threat, but the consequences of infection may end up being with us for years and decades to come."

Parkinson disease is a multi-system disorder that begins years or even decades before its hallmark movement-related symptoms appear. Growing evidence suggests Parkinson disease arises from a complex mix of factors that vary from person to person, including age, genetic predisposition, history of infections, and exposure to certain environmental factors such as pollution or pesticides.

Viral infections in particular may play a role in triggering the earliest stages of Parkinson disease by setting off a cascade that results in the death of brain cells that produce dopamine, a vital chemical messenger whose absence leads to movement issues such as freezing and tremor.

The three cases referenced in the commentary occurred in people without a family history of Parkinson disease and without any known early Parkinson disease symptoms. Two saw an improvement in their Parkinson-like symptoms following treatment with traditional Parkinson disease medications that replenish dopamine; the third recovered spontaneously. Although these medications treat symptoms, they often have challenging side effects and do not slow or stop Parkinson disease progression.

"SARS-CoV-2 is considered a respiratory virus, however, its virulence and pathogenic potential particularly for neurological complications continues to surprise us," Nath said. "Some patients can develop severe neurological manifestations despite mild respiratory symptoms."

Based on evidence from the case studies and what is known about the mechanisms underpinning Parkinson disease, Brundin, Nath, and Beckham suggest three possible ways that COVID-19 infection could contribute to Parkinson disease onset:

COVID-19 is linked to blood clots and other problems with the vascular system, including in the brain. These vascular insults could cause damage to the area of the brain that produces dopamine, which subsequently could result in a loss of dopamine that mirrors Parkinson disease.

There is a demonstrated link between chronic inflammation and Parkinson disease. It is possible that severe inflammation resulting from COVID-19 could trigger brain inflammation and cell death associated with Parkinson disease.

SARS-CoV-2 may be a neurotropic virus, meaning that it attacks the nervous system. Because of this, COVID-19 and Parkinson disease share some early symptoms such as loss of sense of smell and is-sues with the gut. Additionally, infection with SARS-CoV-2 could lead to an increase in alpha-synuclein, a protein associated with Parkinson disease (this has been seen in other viral infections).

Although these cases do not prove that COVID-19 infection causes Parkinson disease, they do suggest a troubling possible relationship between the virus and subsequent neurodegenerative disorders.

"The large number of respiratory cases due to SARS-CoV2 has allowed us to understand and analyze important neurologic complications of severe respiratory virus infections," Beckham said. "It is important that we continue our scientific investigations into this new virus so we understand all of the short and long-term complications of the COVID-19 pandemic."

Going forward, the authors call for long-term studies that follow people who were infected with COVID-19 to monitor them for Parkinson disease development.

Source: News Release
Van Andel Research Institute
October 23, 2020