How early life trauma can contribute to functional neurologic disorder

Feb 14, 2020

In individuals with functional neurologic disorder, the brain generally appears structurally normal on clinical MRI scans but functions incorrectly (akin to a computer software crashing), resulting in patients experiencing symptoms including limb weakness, tremor, gait abnormalities and non-epileptic seizures. In some cases, childhood maltreatment may have been a contributing factor, yet links between risk factors such as childhood abuse and brain mechanisms for the development of functional neurologic disorder remain poorly understood. In a new study published in Molecular Psychiatry, researchers led by investigators at Massachusetts General Hospital examined the brains of individuals who experienced early-life trauma, some with functional neurologic disorder and others without the condition. The findings may provide a better understanding of what happens in the brains of some patients with functional neurologic disorder, as well as those with various other trauma-related brain disorders.

In the study of 30 adults with functional neurologic disorder and 21 individuals whose clinical depression diagnoses served as controls, some of the participants in both groups had experienced early-life maltreatment, as determined through questionnaires. In functional neurologic disorder patients only, differences in the severity of childhood physical abuse correlated with differences in connections between certain regions of the brain--for example, between the limbic regions which control emotions, arousal and survival instincts among other functions, and the primary motor cortex which is involved in voluntary movements.

"Motor and limbic circuits were more strongly interconnected in individuals with functional neurologic disorder reporting a greater severity of childhood physical abuse," explained lead author Ibai Diez PhD, a senior research fellow in Neurology and Radiology at Massachusetts General Hospital. This finding may lead to potentially important insights on the plastic brain mechanisms involved in promoting increased cross-talk between motor control circuits and emotion processing circuits.

In additional assessments, investigators examined how the expression of genes in a publicly available data set from the Allen Institute related to brain areas showing prominent plastic effects correlated to the degree of early-life physical abuse in patients with functional neurologic disorder. As background, some genes in the literature have been shown to increase risk for developing brain disorders after experiencing early-life maltreatment. The researchers found that brain areas showing prominent functional re-organization in patients with functional neurologic disorder were the same brain areas highly expressing genes involved in neuroplasticity and nervous system development.

"Our study has potential implications regarding our understanding of brain-trauma relationships not only in patients with functional neurologic disorder but also across the greater spectrum of trauma-related brain disorders," said senior author David Perez MD MMSc, director of the Massachusetts General Hospital Functional Neurologic Disorder Clinical and Research Programs.

Perez stressed that although childhood maltreatment may be a risk factor for the development of functional neurologic disorder in some individuals, there are many social, environmental, and biological factors that likely influence the development of functional neurologic disorder later in life.

"More work is needed to understand how the brain mechanisms underlying functional neurologic disorder in those without prominent childhood maltreatment may be the same or different as those individuals with functional neurologic disorder with a high burden of childhood adversity," he said.

Source: News Release
Massachusetts General Hospital
February 13, 2020