Mar. 29, 2022
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A prognostic model developed by University of Pittsburgh School of Medicine data scientists and UPMC neurotrauma surgeons is the first to use automated brain scans and machine learning to inform outcomes in patients with severe traumatic brain injuries.
In a study reported today in the journal Radiology, the team showed that their advanced machine-learning algorithm can analyze brain scans and relevant clinical data from patients with traumatic brain injury to quickly and accurately predict survival and recovery at 6 months after the injury.
“Every day, in hospitals across the United States, care is withdrawn from patients who would have otherwise returned to independent living,” said co-senior author David Okonkwo MD PhD professor of neurological surgery at Pitt and UPMC. “The majority of people who survive a critical period in an acute care setting make a meaningful recovery—which further underscores the need to identify patients who are more likely to recover.”
It often takes 2 weeks for patients with traumatic brain injury to emerge from their coma and begin their recoveries—yet patients with severe traumatic brain injury are often taken off life support within the first 72 hours after hospital admission. The new predictive algorithm, validated across two independent patient cohorts, could be used to screen patients shortly after admission and can improve clinicians’ ability to deliver the best care at the right time.
Traumatic brain injury is one of the most pressing public health issues in the United States—every year, nearly 3 million people seek traumatic brain injury care across the nation, and traumatic brain injury remains a leading cause of death in people under the age of 45 years.
Recognizing the need for better ways to assist clinicians, the team of data scientists at Pitt set out to leverage their expertise in advanced artificial intelligence to develop a sophisticated tool to understand the nature of each unique patient’s traumatic brain injury.
“There is a great need for better quantitative tools to help intensive care neurologists and neurosurgeons make more informed decisions for patients in critical condition,” said corresponding author Shandong Wu PhD, associate professor of radiology, bioengineering, and biomedical informatics at Pitt. “This collaboration with Dr. Okonkwo’s team gave us an opportunity to use our expertise in machine learning and medical imaging to develop models that use both brain imaging and other clinically available data to address an unmet need.”
Led by the co-first authors Matthew Pease MD and Dooman Arefan PhD, the group developed a custom artificial intelligence model that processed multiple brain scans from each patient and combined it with an estimate of coma severity and information about the patient’s vital signs, blood tests, and heart function. Importantly, because brain imaging techniques evolve over time and image quality can vary dramatically from patient to patient, the researchers accounted for data irregularity by training their model on different image-taking protocols.
The model proved itself by accurately predicting patients’ risk of death and unfavorable outcomes at six months following the traumatic incident. To validate the model, Pitt researchers tested it with two patient cohorts: one of over 500 patients with severe traumatic brain injury previously treated at UPMC and the other an external cohort of 220 patients from 18 institutions across the country, through the TRACK-TBI consortium. The external cohort was critical to test the model’s prediction ability.
“We hope this research shows that AI can provide a tool to improve clinical decision-making early when a patient with traumatic brain injury is admitted to the emergency room, towards yielding a better outcome for the patients,” said Wu and Okonkwo.
Source: News Release
University of Pittsburgh
April 26, 2022