Gene therapy of neurogenetic disorders
Aug. 30, 2020
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A world-first international study led by the University of South Australia has identified a new drug to stop athletes from developing dementia after sustaining repeated head injuries in their career.
The link between concussion and neurogenerative diseases is well established, but new research findings could halt the progression of chronic traumatic encephalopathy in sportspeople who sustain repeated blows to the head.
Chronic traumatic encephalopathy is a progressive and fatal brain disease associated with the accumulation of a protein known as hyperphosphorylated tau which affects cognition and behavior.
In a paper published in Scientific Reports, UniSA Emeritus Professor Bob Vink and colleagues show how repeated concussions can cause chronic traumatic encephalopathy and a way to block it with a specially developed drug.
The findings will potentially have significant implications for athletes who play contact sports - such as boxers and footballers - as well as military veterans sustaining head injuries in conflict.
The team of researchers from Adelaide, Melbourne and the United States say the brain releases a neurotransmitter called substance P in the event of a head injury, causing abnormal amounts of the tau protein to collect inside neurons.
"Tau protein tangles are a feature of chronic traumatic encephalopathy, which reportedly leads to memory problems, confusion, personality changes, aggression, depression and suicidal thinking," Prof Vink says.
"Our research shows that by blocking substance P with a specific drug, we can prevent the tau protein tangles from developing in the brain and causing neurological problems."
The treatment was successfully tested in animal models, giving hope that chronic traumatic encephalopathy can be prevented in humans.
Prof Vink says the next step is human clinical trials, but that could take several years given that currently chronic traumatic encephalopathy can only be diagnosed post-mortem.
A study of 14,000 Americans over 25 years, published in Alzheimer's and Dementia in March, showed that people who sustained even one head injury were 25% more likely to develop dementia later in life. This risk increased with multiple traumatic brain injuries.
The Guardian also reported in April that an analysis of late AFLW player Jacinta Barclay's brain uncovered neurological damage at age 29, highlighting the risks of repeated concussions to both sexes. Previous research has focused on the impact of brain injuries in male athletes, but females are more likely to sustain concussions.
Source: News Release
University of South Australia
June 7, 2021