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The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched an early-stage clinical trial to evaluate an investigational preventative vaccine for Epstein-Barr virus. Epstein-Barr virus is the primary cause of infectious mononucleosis and is associated with certain cancers and autoimmune diseases. The Phase 1 study, which will be conducted at the NIH Clinical Center in Bethesda, Maryland, is one of only two studies to test an investigational Epstein-Barr virus vaccine in more than a decade.
Epstein-Barr virus is a member of the herpes virus family and one of the most common human viruses. It is spread through bodily fluids, primarily saliva. An estimated 125,000 cases of infectious mononucleosis occur each year in the United States; roughly 10% of those persons develop fatigue lasting six months or longer. Approximately 1% of all Epstein-Barr virus-infected individuals develop serious complications, including hepatitis, neurologic problems, or severe blood abnormalities. Epstein-Barr virus also is associated with several malignancies, including stomach and nasopharyngeal cancers and Hodgkin and Burkitt lymphomas, as well as autoimmune diseases, such as systemic lupus erythematosus and multiple sclerosis.
“A vaccine that could prevent or reduce the severity of infection with the Epstein-Barr virus could reduce the incidence of infectious mononucleosis and might also reduce the incidence of Epstein-Barr virus-associated malignancies and autoimmune diseases,” said NIAID Director Anthony S Fauci MD.
Led by principal investigator Jessica Durkee-Shock MD, of NIAID’s Laboratory of Infectious Diseases, the study will evaluate the safety and immune response of an investigational Epstein-Barr virus gp350-Ferritin nanoparticle vaccine with a saponin-based Matrix-M adjuvant. The experimental vaccine was developed by the Laboratory of Infectious Diseases in collaboration with NIAID’s Vaccine Research Center. The Matrix-M adjuvant was developed by the biotechnology company Novavax, based in Gaithersburg, Maryland.
The vaccine works by targeting Epstein-Barr virus glycoprotein gp350, which is found on the surface of the virus and virus-infected cells. Epstein-Barr virus gp350 is also the primary target for neutralizing antibodies found in the blood of people naturally infected with Epstein-Barr virus. Ferritin, a natural iron storage protein found in cells of all living species, is considered a promising vaccine platform because it can display proteins from the targeted virus in a dense array on its surface. The adjuvant is intended to enhance the immune response induced by the investigational vaccine.
The study will enroll 40 healthy volunteer adults ages 18 to 29 years, half of whom have evidence of prior Epstein-Barr virus infection and half of whom do not have evidence of prior Epstein-Barr virus infection. Participants will be given a series of three 50-microgram injections of the experimental vaccine in the upper arm muscle, followed by 30 to 60 minutes of observation after each dose. The second and third doses will be administered 30 days and 180 days after the initial dose, with follow-up visits between each vaccination and phone calls between visits. Participation is expected to be required for 18 to 30 months, and the trial is expected to last four years. More information about the study is available on https://www.clinicaltrials.gov/ using the identifier NCT04645147.
Source: News Release
National Institutes of Health
May 6, 2022