Neuropharmacology & Neurotherapeutics
Intravenous immune globulin
Mar. 08, 2021
At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas.
Scientists have long believed that a single traumatic brain injury earlier in life may contribute to problems with memory, thinking and depression later in life. In most previous studies, however, research failed to examine the possible role of having a history of exposure to repetitive head impacts, including those leading to "subconcussive" injuries, in these later-life problems. In the largest study of its kind, an association has been found in living patients exposed to repetitive head impacts and difficulties with cognitive functioning and depression years or decades later.
Scientists from the Boston University (BU) Alzheimer's Disease and Chronic Traumatic Encephalopathy (CTE) Centers, the University of California, San Francisco (UCSF), and San Francisco VA Healthcare System teamed up to analyze the records of 13,323 individuals age 40 and older (average age 62) who participate in the internet-based Brain Health Registry. Of those, 725 or 5% of participants reported exposure to previous repetitive head impacts through contact sports, abuse or military service. In addition to repetitive head impact history, the scientists also examined the effects of having a traumatic brain injury with and without loss of consciousness.
Along with self-report questionnaires of repetitive head impact and traumatic brain injury history, participants completed measures of depressive symptoms and computerized cognitive tests. The findings, published in the journal Neurology, reveal that participants with a history of both repetitive head impacts and traumatic brain injury reported greater depression symptoms than those who did not have such history. In addition, when repetitive head impacts and traumatic brain injury were examined separately, a history of repetitive head impacts had the strongest effect on later-life symptoms of depression. The findings were independent of age, sex, racial identity and education level.
"The findings underscore that repetitive hits to the head, such as those from contact sport participation or physical abuse, might be associated with later-life symptoms of depression. It should be made clear that this association is likely to be dependent on the dose or duration of repetitive head impacts and this information was not available for this study," said Michael Alosco PhD, associate professor of neurology at BU School of Medicine (BUSM) and co-director of the BU Alzheimer's Disease Center Clinical Core.
There was a dose-response-like pattern between head trauma and depression symptoms. Specifically, participants without any history of either traumatic brain injury or repetitive head impacts had the fewest symptoms. While depression symptoms increased when a history of traumatic brain injury alone was present, depression symptoms were highest for the groups who had a history of both repetitive head impacts and traumatic brain injury. Indeed, the group that had a history of repetitive head impacts and traumatic brain injury with loss of consciousness reported the most depressive symptoms.
A similar cumulative effect was seen among those exposed to repetitive head impacts and traumatic brain injury on tests of memory, learning, processing speed, and reaction time. Participants with a history of repetitive head impacts or traumatic brain injury had worse performance on some of the tests compared to those without any head trauma history, and those with both a history of repetitive head impacts and traumatic brain injury with loss of consciousness had worse performance on almost all of these computerized cognitive tests.
"These findings add to the growing knowledge about the long-term neurological consequences of brain trauma," said Robert Stern PhD, professor of neurology, neurosurgery and anatomy & neurobiology at BUSM and director of clinical research at the BU CTE Center. "It should be noted that not all people with a history of repetitive hits to the head will develop later-life problems with cognitive functioning and depression. However, results from this study provide further evidence that exposure to repetitive head impacts, such as through the routine play of tackle football, plays an important role in the development in these later-life cognitive and emotional problems," added Stern, one of the senior authors of the study.
A major limitation of the study is that the researchers did not have access to measurements or estimates of the degree of repetitive impact exposure nor traumatic brain injury frequency. In October, BU researchers reported a dose-response relationship between the number of years of exposure to tackle football (regardless of the number of concussions) and the presence and severity of the degenerative brain disease chronic traumatic encephalopathy. In a sample of 266 deceased football players, each year of exposure to tackle football was associated with 30% increased odds of having chronic traumatic encephalopathy and 17% increased odds of having severe chronic traumatic encephalopathy. It is unknown if any subjects in this study have chronic traumatic encephalopathy or any other neurodegenerative disease.
The research team plans to extend their work through continued collaboration between BU and UCSF investigators utilizing data from the Brain Health Registry. "We are excited to partner with BU on this important study that used the Brain Health Registry to increase our understanding on the long-term effects of repetitive head impacts and traumatic brain injury," said Michael Weiner MD, PI of the Brain Health Registry and professor-in-residence in radiology and biomedical imaging, medicine, psychiatry and neurology at UCSF. "The Brain Health Registry is a novel and exciting resource for both the scientific community and the general public. It allows for large-scale recruitment, screening and study of dementia, and more than 60,000 individuals across the world are enrolled. It offers a way for the general public to track their thinking, memory, mood, and behavior over time, and also serves as a readiness registry for future research and clinical trials of prevention and treatment." You can visit the BHR here: http://bit.ly/brainhealthreg.
Source: News Release
Boston University School of Medicine
June 26, 2020