Research uncovers new insights on ALS and points to a potentially promising treatment strategy

New research provides a better understanding of the mechanisms behind the development of amyotrophic lateral sclerosis and points to a potential treatment strategy. The work was led by investigators at the Healey Center for Amyotrophic Lateral Sclerosis at Massachusetts General Hospital (MGH) and is published in Molecular Neurobiology.

Amyotrophic lateral sclerosis, a degenerative condition without a cure, attacks brain and spinal cord nerve cells to progressively affect individuals’ ability to move, speak, eat, and even breathe. Previous studies have implicated dysfunction within mitochondria, which generate energy within cells, as playing an important role in the development of amyotrophic lateral sclerosis. Also, studies in Alzheimer disease have linked changes in mitochondrial function to interactions between an abnormal form of tau, which accumulates in the brains of patients with Alzheimer disease, and a mitochondrial protein called dynamin-related protein 1 (DRP1). Piecing these bits of information together, Ghazaleh Sadri-Vakili PhD, director of the NeuroEpigenetics Laboratory at the MassGeneral Institute for Neurodegenerative Disease and the Healey Center for amyotrophic lateral sclerosis at MGH, and her colleagues examined whether interactions between this abnormal tau with DRP1 might also promote mitochondrial dysfunction in amyotrophic lateral sclerosis, and whether reducing tau could be a novel and promising therapeutic approach to fight the disease.

The team found that in brain tissue from deceased patients who had amyotrophic lateral sclerosis, the abnormal form of tau is present, is located where tau is not normally found, and interacts with DRP1. When cells were grown in contact with deceased amyotrophic lateral sclerosis patients’ brain tissue that contained abnormal tau, the cells’ mitochondria fragmented and oxidative stress increased. Importantly, reducing tau with a specific degrader reversed these effects, reducing mitochondrial fragmentation and lowering oxidative stress.

“We demonstrated for the first time that targeting tau with a new class of small molecules that selectively degrade it can reverse the amyotrophic lateral sclerosis-induced changes in mitochondria’s shape and function, highlighting tau as a potential therapeutic target,” says Sadri-Vakili.

Source: News Release
Massachusetts General Hospital
November 10, 2021