Neuropharmacology & Neurotherapeutics
May. 29, 2021
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The diagnosis of Parkinson disease is currently based on consensus clinical criteria. A novel study reported in the Journal of Parkinson’s Disease has found that the presence of neuronal deposits of the biomarker phosphorylated alpha-synuclein (p-syn) in the brain and the skin of patients with Parkinson disease distinguishes them from individuals with symptoms of parkinsonism due to the accumulation of another protein, tau. This development may help the early identification and differential diagnosis of Parkinson disease among the various parkinsonism subtypes.
The main parkinsonian symptoms are shared with other synucleinopathies, as well as with atypical parkinsonism, including progressive supranuclear palsy and corticobasal syndrome, both of which are due to the accumulation of another protein, tau. Despite the clinical overlap with Parkinson disease, progressive supranuclear palsy is characterized by 4-repeat tau deposits, mainly in the basal ganglia, brainstem, and cerebellum, and corticobasal syndrome is a clinical syndrome with a heterogeneous underlying neuropathology, represented mainly by tauopathies but also by synucleinopathies.
“Research in Parkinson disease and other neurodegenerative disorders is to find treatments able to halt and ideally prevent the accumulation the pathological proteins responsible for the different disorders. Our lab, led by Prof. Rocco Liguori and Dr. Vincenzo Donadio, has spent the last decade looking for reliable biomarkers of Parkinson disease and related disorders to achieve an accurate and early diagnosis,” explained corresponding author Maria Pia Giannoccaro PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna and IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
“This research sprang from the same effort. Our aim was to see if we could distinguish Parkinson disease from two potential mimics, progressive supranuclear palsy and corticobasal syndrome, and to explore the potential for using this approach to support clinical diagnosis,” Dr. Giannoccaro continued.
Investigators recruited 26 patients with Parkinson disease, 26 patients with either progressive supranuclear palsy (18) or corticobasal syndrome (8), and 26 healthy individuals from May 2014 to April 2017. All individuals underwent skin biopsy in three sites, the leg, the thigh, and the cervical area, to study p-syn deposits in skin nerves. They found that all except two of the progressive supranuclear palsy or corticobasal syndrome patients had no skin p-syn deposits, as well as all the healthy individuals. Conversely, all patients with Parkinson disease showed p-syn deposition.
The investigators were surprised by the finding that two patients diagnosed with progressive supranuclear palsy and corticobasal syndrome, respectively, had p-syn skin deposits. One possibility is that these two patients were misdiagnosed, however, the diagnosis was confirmed by clinical and MRI findings. Another intriguing possibility is that some patients have a mixed pathology with multiple neurodegenerative disorders occurring at the same time. Both patients had some atypical features more typical of Parkinson disease that could suggest an atypical synucleinopathy presentation.
“To our knowledge this is the largest study comparing in vivo the peripheral deposition of misfolded alpha-synuclein in Parkinson disease and progressive supranuclear palsy or corticobasal syndrome cases,” commented Dr. Giannoccaro. “We showed that the presence of skin p-syn deposits accurately distinguishes patients with Parkinson disease from those with atypical parkinsonism. Early differentiation and accurate in vivo diagnosis are important for adequate clinical management and patient care since the treatment and prognosis of Parkinson disease, progressive supranuclear palsy and corticobasal syndrome are different.
The investigators recommend further studies including larger samples of patients to confirm these results. Moreover, in the near future, it could be relevant for the recruitment of patients in clinical trials of potential disease-modifying therapies.
Parkinson disease is a slowly progressive disorder that affects movement, muscle control, and balance. It is the second most common age-related neurodegenerative disorder affecting about 3% of the population by the age of 65 and up to 5% of individuals over 85 years of age.