More than 2.5 million people in the United States alone experience a traumatic brain injury each year. Some of these people are plagued by a seemingly unrelated cascade of health issues for years after their head injury, including fatigue, depression, anxiety, memory issues, and sleep disturbances.
A collaborative team, led by Dr. Randall Urban, The University of Texas Medical Branch at Galveston's Chief Research Officer and Professor of Endocrinology, has spent the past 20 years investigating this post-traumatic brain injury syndrome. The team has learned more about how a traumatic brain injury triggers a reduction in growth hormone secretion and why most patients with traumatic brain injury improve after growth hormone replacement treatment.
The studies led to the definition of the syndrome as brain injury associated fatigue and altered cognition, or BIAFAC, as recently described in a commentary published by Drs Urban and Brent Masel, UTMB Professor of Neurology, in the Journal of Neurotrauma. Detailed information on the team's two most recent advances also in the Journal of Neurotrauma.
The team's work on brain injuries began in the late 1990's when Galveston philanthropist Robert Moody asked the team whether traumatic brain injury caused dysfunction of the hormones made by the brain's pituitary gland and funded research for the study. His son, Russell, had suffered a serious traumatic brain injury during a car accident and was seeking ways to improve the life of his son and others living with brain injuries.
The team has been building on the discovery that traumatic brain injury triggers a long-term reduction in growth hormone secretion that is linked with BIAFAC. Most patients with traumatic brain injury experience dramatic symptom relief with growth hormone replacement therapy, but the symptoms return if the treatment stops. The researchers are trying to better understand BIAFAC and exactly how and why growth hormone replacement works so well in order to develop new interventions.
"We already knew that even mild traumatic brain injury triggers both short- and long-term changes to functional connections in the brain," said Urban. "Growth hormone administration has been extensively linked with both protection and repair of the brain following damage or disease, however we didn't know much about the particular mechanisms and pathways involved."
They examined 18 people with a history of mild traumatic brain injury and inadequate growth hormone secretion. The subjects received growth hormone replacement in a year-long, double-blind, placebo-controlled study and were assessed for changes in physical performance, resting metabolic rate, fatigue, sleep quality, and mood. Functional magnetic resonance imaging was also used throughout the year to assess changes in brain structure and functional connections.
The study showed that growth hormone replacement was linked with increased lean body mass and decreased fat mass as well as reduced fatigue, anxiety, depression and sleep disturbance. It was also found, for the first time, that these improvements were associated with better communications among brain networks that have been previously associated with growth hormone deficiency. They also noted increases in both grey and white matter in frontal brain regions, the "core communications center of the brain," that could be related to cognitive improvements.
"We noticed that patients with traumatic brain injury had altered amino acid and hormonal profiles suggesting chronic intestinal inflammation, so we recently completed a trial to investigate the role of the gut-brain axis in the long-lasting effects of traumatic brain injury," said Urban. "We compared the fecal microbes of 22 patients with moderate/severe traumatic brain injury residing in a long-term care facility with 18 healthy age-matched control subjects, identifying disruptions of intestinal metabolism and changes in nutrient utilization in traumatic brain injury patients that could explain the reduced growth hormone function."
The results suggest that the people with traumatic brain injury-related fatigue and altered cognition also have different fecal bacterial communities than the control group. Urban said that the findings suggest that supplementing or replacing the dysbiotic intestinal communities may help to ease the symptoms experienced after traumatic brain injury.
"These two studies further characterize BIAFAC and act as a springboard for new treatment options," said Urban. "We hope that the publications will focus the collective wisdom of the research community to better understand and treat this syndrome, providing hope for many. Because these symptoms can manifest months to years after the initial injury and as this cluster of symptoms hasn't been previously grouped together, it often goes unidentified in the medical community."
Source: News Release
University of Texas Medical Branch at Galveston
January 21, 2020