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Vagus nerve stimulation lowers costs of care for children with uncontrolled epilepsy

Vagus nerve stimulation, sometimes referred to as a “pacemaker for the brain,” involves a stimulator device that is implanted under the skin in the chest, with a wire that is wound around the vagus nerve in the neck. It helps prevent seizures by sending regular, mild electrical pulses to the brain. Typically, the patient is not aware the device is operating.

A new study from Ann & Robert H. Lurie Children’s Hospital of Chicago published in the journal Epilepsia examined a population of pediatric patients with drug-resistant epilepsy. For these patients, the study found that the patients who received vagus nerve stimulation, when used with antiseizure medications, had lower hospital costs compared to the use of antiseizure medication alone. The study found that the patients treated with antiseizure medication plus vagus nerve stimulation had savings of over $3,000 of epilepsy-related annual costs per year, compared to treatment with antiseizure medication only. These findings mirror the team's previous report of children with drug-resistant epilepsy having significantly decreased inpatient healthcare utilization following vagus nerve stimulation plus antiseizure medication compared to those treated with antiseizure medication alone. The study on healthcare utilization was published in Epilepsy & Behavior.

“We take a health services research perspective on the patients' journey with a challenging disease process of drug-resistant epilepsy that has not been met with a cure. For patients with drug-resistant epilepsy, reducing seizure burden and addressing quality of life are important goals. We quantify aspects of outcomes of surgical therapies and medical therapies, and we assess the impact on health care costs and utilization. To the patients, families, health care systems, health care advocates, and policymakers, these are important results,” said senior author Sandi Lam MD MBA, Division Head of Neurosurgery at Lurie Children’s and Professor of Neurological Surgery at Northwestern University Feinberg School of Medicine. “While we show lower costs to the health care system following vagus nerve stimulation surgery, from a practical standpoint it means fewer hospital admissions because of seizures. Patients spend their days at home instead of in the hospital.”

The study is unique in multiple ways. There has been no previous research focusing on children with drug-resistant epilepsy and comparing the outcomes of those who had vagus nerve stimulation and antiseizure medications and those who only received antiseizure medications. The study also provides a breakdown of costs by site of care (inpatient, outpatient, and Emergency Department). The study researchers found that emergency department costs decreased more for children treated with vagus nerve stimulation and antiseizure medication, compared to antiseizure medication alone. While average annual total costs were higher in the antiseizure medication-only cohort, the researchers also observed that outpatient care costs for vagus nerve stimulation with antiseizure medication were higher than antiseizure medication alone. The study authors note that it is not surprising that children required more outpatient care shortly after vagus nerve stimulation implantation, since device adjustment for each patient is necessary in this time period. Outpatient costs for children with vagus nerve stimulation decreased dramatically in the second year. Future studies warrant additional focus on costs and patterns of care in longer term follow-up.

Research with national data do not substitute for clinical research. Each patient with epilepsy presents a unique case requiring tailored clinical care that should be managed at a comprehensive Level 4 NAEC pediatric epilepsy center like Lurie Children's. Large studies with health services research can inform future research as well as gaps and opportunities in health care delivery. The study shows that surgical options should be a part of the epilepsy treatment armamentarium. While future studies will look at cranial epilepsy surgery outcomes, this study was limited to vagus nerve stimulation and did not include epilepsy surgery on the brain, which is an important way of epilepsy treatment.

The study included children (0 to 17 years of age) who were diagnosed with refractory epilepsy, with 1113 patients treated with antiseizure medication plus vagus nerve stimulation and 3471 patients treated with antiseizure medication only. Data were sourced from the Children’s Hospital Association’s Pediatric Health Information System (PHIS) database, which contains inpatient, emergency department, ambulatory, and observation encounter level data from more than 44 children’s hospitals in the United States. Patients in the study were followed one year prior and two years after meeting pre-determined criteria for refractory epilepsy.

Source: News Release
Ann & Robert H. Lurie Children's Hospital of Chicago
March 25, 2022

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