Behavioral & Cognitive Disorders
Dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative dementia characterized by the postmortem findings of pathologically misfolded alpha-synuclein protein aggregations in the form of Lewy bodies and Lewy neurites in the CNS. The majority of patients with DLB also have a moderate to severe level of Alzheimer disease plaque and tangle pathology sufficient for a secondary neuropathological diagnosis of Alzheimer disease. Clinically, this syndrome is associated with a prominent dementia with simultaneous, or later developing, extrapyramidal symptoms (ie, parkinsonism); however, not all patients with DLB develop clinical parkinsonism.
Nov. 20, 2017