ALS-like disorders of the Western Pacific
Amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS-PDC), also known as lytico-bodig, is an endemic neurodegenerative disorder of the Western Pacific islands. It is a slowly progressive degenerative disease with a spectrum of clinical presentation that can include features of amyotrophic lateral sclerosis, parkinsonism, and dementia. The cycad-derived toxin cycasin as well as the neurotoxic nonprotein amino acid beta-methyl-amino-L-alanine have been postulated as potential etiologies.
Aug. 25, 2020