Oligodendrogliomas are diffusely infiltrating and chemoresponsive gliomas defined by the presence of mutated IDH1 or IDH2 and whole-arm chromosomal losses of 1p and 19q. Their growth trajectory is typically slower compared to astrocytomas, though no less fatal in advanced stages of disease. The goal of treatment is to prolong survival and delay further progression, and a multidisciplinary approach with surgery, radiation, and chemotherapy is often warranted.
Jul. 22, 2021