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Pontocerebellar hypoplasia type 2 (synaptophysin stain)

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This microscopic section of the cerebellum in pontocerebellar hypoplasia type 2 shows the typical fragmentary loss of neurons with islands of preserved neurons. This aspect cannot be seen on MRI. For the pathologist this is one of the hallmarks of the disease. Low magnification, synaptophysin stain. (Contributed by Dr. Peter Barth.)