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Tomacula in Charcot-Marie-Tooth disease type 1B (immunohistochemical appearance)

Sural nerve, indirect immunofluorescence. Cryosections were incubated with a rabbit polyclonal antiserum to myelin protein zero, followed by a Texas red-conjugated antibody to rabbit IgG. The antigen is expressed on myelin sheaths including the tomaculum (arrow heads). (magnification x835) (Contributed by Dr. Florian Thomas.)

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Associated Disorders

  • Congenital hypomyelination neuropathy
  • Dejerine-Sottas syndrome
  • Hereditary motor and sensory neuropathy type 3
  • Peroneal muscular atrophy