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Interaction of folate cycling with the remethylation of homocysteine to methionine

Folate metabolism. The interaction of folate cycling with the remethylation of homocysteine to methionine under the action of methionine synthase. Vitamin B12 is an additional cofactor for this reaction. Abbreviations (in alphabetic order): B12, cobalamin; MS, methionine synthase; 5MTHF, 5-methyl-terahydrofolate; methylenetetrahydrofolate dehydrogenase; SAH, S-adenosyl homocysteine; SAM, S-adenosyl methionine; THF, tetrahydrofolate. (Image by Douglas Lanska MD MS MSPH.)

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