Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Typical muscle biopsy findings in inclusion body myositis

(A) Cross-sections of H&E-stained muscle biopsies demonstrate scattered inflammatory foci with lymphocytes invading or surrounding healthy-appearing muscle fibers combined with autophagic vacuoles with bluish-red material in areas not invaded by T cells and chronic myopathic features (increased connective tissue, atrophic and hypertrophic fibers). (B) In clinical inclusion body myositis, there is inflammation without vacuoles. (C) Characteristic in typical inclusion body myositis are COX-negative fibers and (D) crystal violet-positive congophilic amyloid deposits within the vacuoles. (Contributed by Dr. Marinos Dalakas.)

Related Media

Associated Disorders

  • Chronic denervation
  • Collagen vascular diseases
  • Dermatomyositis
  • Familial inclusion body myositis
  • Infections
  • Systemic immune-medicated disorders
  • Vacuolar distal myopathies