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San Diego, CA 92108-2134
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Shortened, crumpled, and hypomineralized long bones are evident in this radiograph of the right upper arm. (Contributed by Dr. Joseph Siebert.)
Childhood Degenerative & Metabolic Disorders
Apr. 25, 2020
Stroke & Vascular Disorders
Supportive care for ischemic stroke patients has 2 main objectives: (1) to minimize injury to potentially ischemic brain tissue and (2) to prevent and treat the many neurologic and medical complications that may occur in the immediate period following stroke. Lowering blood pressure at acute ischemic stroke onset below general guidelines values of 220/120 should be avoided; lowering pressures acutely to just below 185/110 is recommended when thrombolytic therapy is intended. Volume repletion and circulatory volume maintenance is crucial.
Mar. 11, 2020
Nov. 07, 2020
Amyloidosis refers to the extracellular deposition of fibrils composed of low weight chain of a variety of normal serum proteins. The autosomal dominant hereditary transthyretin amyloidosis (hATTR) and the acquired light chain (AL)-amyloidosis, the result of a plasma cell dyscrasia, are the 2 most common types of amyloidosis associated with peripheral neuropathy. In both, the main presentation is a painful, length-dependent small fiber neuropathy starting in the feet, with numbness, burning and allodynia, which can be particularly worse at night.
Feb. 12, 2020
Neuro-Ophthalmology & Neuro-Otology
Leber hereditary optic neuropathy is a disease caused by various mutations in the mitochondrial genome and, as such, is inherited only via the maternal ovum as spermatozoa do not have mitochondria. It usually manifests as sequential binocular acute painless vision loss in sons of carrier mothers. The typical vision loss pattern is decreased visual acuity, with most patients seeing 20/200 or worse, a visual field defect involving the blind spot, and central fixation (cecocentral scotoma).
Dec. 19, 2020
Apr. 06, 2020
Feb. 21, 2021
Epilepsy & Seizures
Jun. 03, 2020