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Sacral agenesis (photomicrograph showing dysplasia of sacral spinal cord segment in fetus)

The ependyma of the central canal is discontinuous and divided into 2 portions with intervening neural tissue; the central canal is also much larger than expected at this age. Ventral horns are fused in the ventral midline and motor neurons are few. A well-formed dorsal median raphe separating the dorsal columns of the 2 sides is absent. (Hematoxylin-eosin; x40) (Used with permission. Sarnat HB. Cerebral dysgenesis. Embryology and clinical expression. New York: Oxford Univ Pr, 1992.)

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Associated Disorders

  • Anorectal malformations
  • Anterior meningocele
  • Hirschsprung disease
  • Maternal diabetes mellitus
  • Meningomyelocele
  • Recto-meningeal fistula
  • Sacral teratoma