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Length-dependent atrophy in Charcot-Marie-Tooth disease type X

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Image of Patient A, aged 61 years. Note the loss of bulk in the muscles below the knee and in the hands (Hahn AF, Brown WF, Koopman WJ, Feasby TE. X-linked dominant hereditary motor and sensory neuropathy. Brain 1990;113:1511-25). (Reproduced with permission of Oxford University Press.)