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Transverse section of medulla comparison shows normal pyramids

Transverse section of the medulla from an 80-year-old comparison shows the normal pyramids (right outlined in solid white line in a). The medial lemniscus is outlined by the white dashes (a and b). Transverse section of medulla from a patient with a L1CAM mutation demonstrates absence of the pyramids (b). (Contributed by Dr. William Graf.)

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Associated Disorders

  • CRASH syndrome
  • Complex spastic paraplegia
  • MASA syndrome