Study demonstrates the impact of traumatic brain injury in children extends beyond initial injury

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A new study, published today in JAMA Network Open, reveals that schoolage children and adolescents with medically diagnosed traumatic brain injury have significantly higher rates of anxiety/depression, and strong family support and resilience helps alleviate some of it.

Researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, and University of Washington analyzed associations between medically diagnosed traumatic brain injury and mental (anxiety and depression) and physical (frequent headaches and chronic pain) health outcomes among U.S. children and teens aged 6 to 17 years and evaluated whether these associations varied by level of family resilience. They found that children and teens with traumatic brain injury had a significantly higher prevalence of poor health than those without traumatic brain injury, along with increased odds of current anxiety, frequent headaches, and chronic pain.

“Our study shows that the impact of traumatic brain injury in children often extends well beyond the initial injury,” said Henry Xiang MD MPH PhD MBA, principal investigator in the Center for Injury Research and Policy and senior author of the study. “Children who experience traumatic brain injury face increased risks of mental health challenges such as anxiety and depression, highlighting the importance of routine mental health screening and long-term follow-up care.”

The study also found that family resilience was associated with decreased odds of depression after traumatic brain injury. Family resilience describes how families respond to stress, communicate effectively, and mobilize collective strengths when facing crisis or major family events. “One of the most encouraging findings from our research is that family resilience appears to play an important role in a traumatic brain injury patient’s recovery,” said Xiang. “Children recovering from traumatic brain injury who grow up in supportive families may have lower risks of long-term mental health problems. Strengthening family support systems and resilience may be an important pathway to improving traumatic brain injury patients’ long-term outcomes.”

These findings underscore the importance of strategies families can use to build resilience during recovery.

“Recovery following brain injury in children is about so much more than the child themselves – recovery happens in many contexts with many people, with home and primary caregivers being some of the most important,” said Christine Koterba PhD ABPP, pediatric neuropsychologist at Nationwide Children’s, who was not involved in this study. “I see how recovery actually happens outside the brain, in environments where children spend their time surrounded by the steady caregivers in their lives. This study opens the door for future research focused on caregiver resilience.”

Source: News Release
Nationwide Children's Hospital
April 13, 2026