Spinal ependymoma

Jai Grewal MD (Dr. Grewal of the Long Island Brain Tumor Center at Neurological Surgery, PC, received research funding from Northwest Biotherapeutics and consulting fees from Novocure.)
Harpreet K Grewal MD (Dr. Grewal of JGMDPC in Roslyn, New York, has no relevant financial relationships to disclose; Dr. Grewal's spouse received research funding from Northwest Biotherapeutics and consulting fees from Novocure.)
Edward J Dropcho MD, editor. (Dr. Dropcho of Indiana University Medical Center has no relevant financial relationships to disclose.)
Originally released April 7, 1994; last updated February 24, 2015; expires February 24, 2018

Overview

The authors provide an updated summary of spinal ependymomas, highlighting new molecular features of the most common primary intraspinal tumor of adults. The update also incorporates newly published epidemiological data, surgical treatment options, and briefly comments on the occurrence of these tumors in pregnancy.

Historical note and terminology

In 1887 Horsley performed the first reported successful removal of an intradural, extramedullary tumor (Gowers and Horsley 1888). With the help of Sir William Gowers, Horsley removed a "fibromyxoma" overlying the spinal cord at the T4 level. Postoperatively, the patient developed a debilitating pain syndrome but later experienced a full neurologic recovery. In the following 50 years, pioneering neurosurgeons such as Elsberg, Frazier, and Cushing took particular interest in extramedullary tumors, recognizing their frequently benign nature and often dramatic recovery from profound neurologic deficit (Frazier 1918; Elsberg 1925; Cushing and Eisenhardt 1938). In 1911 Elsberg and Beer reported the first successful removal of an intramedullary spinal cord tumor (Elsberg and Beer 1911). Frazier also commented on the potential for the removal of encapsulated intramedullary neoplasms (Frazier 1918). However, early attempts at removal of intrinsic intramedullary spinal cord tumors were associated with an unacceptable operative morbidity and mortality.

For the next several decades, there was little impetus to modify the approach of biopsy, dural decompression, and radiation therapy, despite the recognition that after a relatively short remission, serious disability or death ensued. This "traditional" attitude was based on the assumption that it was not feasible to carry out extensive removal of tumors from within the center of the spinal cord without inflicting additional neurologic injury (Coxe 1961; Guidetti et al 1981). In 1954 Greenwood, with the aid of bipolar cautery and loupe magnification, reported 6 patients who underwent complete removal of intramedullary ependymomas (Greenwood 1954). By 1963 Greenwood had treated 9 patients with surgery alone. There was no tumor recurrence in his surviving patients (7) with a mean follow-up of 9 years (Greenwood 1963). With time, it has become clear that the majority of intramedullary spinal ependymomas can be radically excised with an acceptable morbidity and mortality, and a low incidence of recurrence (Guidetti 1967; Mork and Loken 1977; Malis 1978; Stein 1979; Fischer and Mansuy 1980; Guidetti et al 1981; Cooper and Epstein 1985; Cooper 1989; Ahyai et al 1990; McCormick et al 1990; Whitaker et al 1991; Ferrante et al 1992; Clover et al 1993; Epstein et al 1993).

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